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KMID : 0371320030640030269
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Journal of the Korean Surgical Society
2003 Volume.64 No. 3 p.269 ~ p.274
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Acute Arterial Occlusion Associated with Protein C and S Deficiencies
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Jung Eun-Young
Kim Yong-Ho
Jang Hyuk-Jai
Kim Ji-Su
Cho Yong-Pil
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Abstract
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Sudden acute arterial occlusion can result from a multitude of pathological processes. Although the appearance and the secondary effects of an acute arterial occlusion are similar regardless of the underlying cause, the treatment and prognosis are different. Therefore, establishing a correct diagnosis is crucial. Acute arterial occlusion is most frequently a complication of ischemic cardiac disease, with an atrial fibrillation occurring in most patients. An identifiable noncardiac source of the acute arterial occlusion can be found in 5~10% of patients. Howerver, in these cases, the specific source of the occlusion cannot be determined clinically or even at autopsy. Possible hypercoagulable states should be suspected and appropriately evaluated, particularly in patients with no history of antecedent occlusive disease who present with sudden arterial occlusions, or in patients with malignant disease. Protein C and protein S deficiencies are frequently described as a cause of the hypercoagulable states. We reported 3 cases of acute arterial occlusion associated with protein C and S deficiencies.
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KEYWORD
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Acute disease, Arterial occlusion, Protein C, Protein S, Deficiency
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